![]() ![]() ("UNITY"), a biotechnology company developing therapeutics to slow, halt, or reverse diseases of aging, today announced results from Part A of the Phase 2 ENVISION study of UBX1325 in patients with wet age-related macular degeneration (AMD) who were not achieving optimum benefit with their ongoing anti-VEGF therapy. UNITY Biotechnology Announces Results from Phase 2 ENVISION Study of UBX1325 in Patients with Wet Age-Related Macular Degeneration More than half (52%) of patients who received UBX1325 did not require anti-VEGF treatment throughout the 24 weeks of the trial, UNITY reported. Patients were already receiving aflibercept when they enrolled in the trial, but benefit from the therapy was not optimal, according to the press release. UBX1325 monotherapy, meanwhile, reduced letters by 0.8 from baseline. The 3.5-letter gain with aflibercept was mostly maintained for the study's duration. The trial used the Early Treatment Diabetic Retinopathy Study (ETDRS) to assess the therapies, which revealed an early and unexpected visual gain of 3.5 ETDRS letters with aflibercept, according to Unity. The trial involved 51 patients with wAMD who received either two 10 mcg doses of UBX1325 at week zero and week four or anti-VEGF agent aflibercept 2 mg every eight weeks. ![]() The 24-week data are from the Part A portion of the proof-of-concept Envision study of UBX1325, a Bcl-xL inhibitor. This sent the biotech's shares tumbling 46% in premarket trading on Monday. UNITY Biotechnology's lead asset, UBX1325, failed to show non-inferiority to Regeneron's anti- VEGF drug aflibercept in a Phase II wet age-related macular degeneration (wAMD) trial. UNITY Shares Nearly Halved after Lead Asset Fails to Match Regeneron's Eylea The conclusion adopted by the rest of the industry is that systemic, whole-body clearance of senescent cells is required to remove enough of the harmful effect of the senescence-associated secretory phenotype (SASP) on tissue function to produce meaningful gains for patients. Unfortunately for UNITY investors, the outcome has been a demonstration, first in the knee, and now in the eye, that localized removal of senescent cells produces some benefit, but not as much as hoped, and not enough to show a clear advantage in human trials. Adopting a localized injection strategy is a time-worn approach intended to make things easier with regulators, as the much lower, localized dose means that there is a greatly reduced risk of side-effects. UNITY Biotechnologies chose to pursue localized administration of senolytics in their initial phase 1 and phase 2 trials for both knee osteoarthritis and macular degeneration. The present consensus is that the senescent cells present in the rest of the body are producing a significant contribution by their signaling: those cells may be more distant, and their contributions thus more dilute, but there are a lot more of them. While adding senescent cells to a joint is sufficient to provoke the onset of osteoarthritis, clearing senescent cells from only the joint region is not sufficient to produce significant patient benefits. More information is available at or follow us on Twitter and LinkedIn.Most of the research relevant to the question of whether localized clearance of senescent cells can effectively treat age-related conditions has taken place in the context of osteoarthritis. UNITY’s current focus is on creating medicines to selectively eliminate or modulate senescent cells and thereby provide transformative benefit in age-related ophthalmologic and neurologic diseases. UNITY is developing a new class of therapeutics to slow, halt or reverse diseases of aging. The webcast of the presentation will be accessible here and through the “Investors and Media” section of our website, under “Events & Presentations.” (“UNITY”), a biotechnology company developing therapeutics to slow, halt, or reverse diseases of aging, today announced that the Company’s Management will provide a corporate update and participate in one-on-one investor meetings at the SVB Securities Global Biopharma Conference on Wednesday, Februat 11:20 AM ET. 15, 2023 (GLOBE NEWSWIRE) - UNITY Biotechnology, Inc. ![]()
0 Comments
![]() ![]() You will need the base game Prison Architect to access this DLC content. You can also run a local business in the prison with the inmates to earn extra money and give them valuable work skills in the process.Build Double Fences It can be expensive, but over. ![]() The opposite is also true sentences can be extended if they haven’t been good lately and are repeat offenders (people who go back to prison more than once) players will also be rewarded for successful rehabilitation or fined with repeat offenders. This is a after all so having a well-designed prisoner is key to keeping security tight while reducing costs. Behavior system: As mentioned before inmates can get out early if they generally have good behavior.Double click on Game icon to play the game. After installation complete, go to the Installed Game location. Open Prison Architect folder, double click on Setup and proceed install. These Programs can remove negative traits from inmates, you will see improvements in them in no time. How to Install: Extract the game using Winrar or 7zip. You are the warden and designing your prison to keep the most dangerous prisoners in line is what you are trying to do in Prison Architect: Second Chances. Examples of the new programs include Animal therapy, Conflict Resolution, and Meetings with Civilians.Immerse yourself in the prison life with the base game, the original soundtrack + digital artbook, and a collection of Prison Architect expansions. ![]() Get everything you need to run a top-notch correctional facility. Cells are where your prisoners stay for the duration of their sentence. Prison Architect - Total Lockdown Bundle. Key Features Return to Reform: New programs, such as Animal Therapy, Meetings with civilians, and Conflict Resolution classes led by forme. Prison Architect Second Chances is the 6 th DLC for the game Prison architect The DLC provides new ways to rehabilitate and reform your inmates, programs that might reduce their prison sentences for good behavior, programs that will give them a better chance at staying out of prison once they’re free. Prison Architect Second Chances-PLAZA Free Download skidrow codex PC Game direct link. Prison Architect: Second Chances gives your inmates a fresh start with reform and rehabilitation features, helping them improve behaviors and reduce sentences. ![]() ![]() ![]() It lets your client manage whatever’s going on, with less worry of cracks, breaks, and lifting because it’s so resilient.” The biggest benefit of acrylic nails is durability. Many nail technicians are experienced in working with this type of nail, so you don’t have to search very hard to find someone skilled in this type of artificial nail. Acrylics are affordable, costing at an average of $35 for a full set and $15 for refills. The finished product is cured normally by air drying.Īcrylics are very popular, many nails salons offer the service. This ball is placed on the nail bed and patted into place. A nail tip is applied to the nail, then a ball is created by dipping a brush into liquid monomer and placing the wet brush in powder polymer. Shellac manicure typically last two weeks without chipping, and a professional manicurist is needed to remove the polish.Īcrylics, the most popular artificial nail, are a combination of a liquid and powder that creates a hard, protective layer over the natural nail. Unlike gels that require extensive filing and soaking to remove, most shellac can be removed by soaking the nail in a solution of 99 percent acetone. Applied by a manicurist, shellac nails still require time under an ultraviolet light to harden, however the cure time is much shorter, only 10 to 15 seconds. Gel nail polish requires extensive soaking and filing by a manicurist for removal.įirst offered by Creative Nail Designs in 2010, shellac manicures combine the ease of traditional polish with some of the endurance of gel polishes. The resulting manicure is extremely durable, lasting anywhere from two to four weeks without a chip. Ultraviolet light reacts with the formula of the gel polish to speed up the drying time and harden the polish. A coat of gel nail polish is applied, and again the nails are set under the ultraviolet light to dry. Nails are cleaned and buffed and a specially formulated base coat is applied and set under an ultraviolet light for 1 to 3 minutes. Gel nails come in a wide range of colors, but each time a client wishes to change her nail polish they must be removed by a professional manicurist to avoid damage.Ī gel polish manicure delivers the same durability of gel nails by using a specially formulated gel nail polish. The gels are stronger than acrylics, and do not yellow or crack as easily. The adhesive cures for 1 to 2 minutes and thin, lightweight gel nails are pressed on. The nail is filed and a special adhesive is applied. This is an art best left to the trained professional while kits are available online, gel manicures require expensive equipment and precise application.Īlthough more flexible and durable then traditional acrylic nails, gel nails can be applied in a similar manner. ![]() There are several types of gel manicures that range in intensity and strength. Unlike traditional nail polishes, gel nail polish and nail enhancements use cutting-edge technology to create long-wearing nail designs. Gel manicures are an excellent alternative for fashionistas who are looking for durable and colorful nail treatments. They are also more durable than acrylic nails, won’t discolor over time and they have a more realistic appearance. ![]() LCN Gel Nails are non-porous and do not weaken the wearer’s natural nails, but protect them. They are also easier to apply and remove. The LCN nail is safer for nail technicians because they do not contain harmful fumes or chemicals. The process makes the nails flexible and strong, The LCN nail resin is a derivative of the dental resin that was used for infilling teeth. This type of resin becomes hard when cured in the special light unit used in salons. Light cured nails are different than normal gel nails because they use light-cured synthetic resins. The type of gel used in these nail extensions is free from acids and harmful chemicals that erode the nail beds. LCN nails are made of a agel-like cured resin. They are also considered to be the most realistic looking nail extensions because of their clarify and honey-like texture. LCN nails are free of harmful chemicals that damage nails. They are known for their lightweight flexibility and long lasting durability. It is a cosmetic fingernail extension considered to be a superior alternative to acrylics. LCN nails is an abbreviation of light concept gel nails. ![]() SeptemPosted by White Lotus Day Spa in Blogger 70727 ![]() ![]() ![]() ![]() And if you've got a lot of speech to transcribe, no problem! EaseText Audio to Text Converter can handle batch transcription with ease. With EaseText Audio to Text Converter, you can transcribe speech in real-time, making your life a whole lot easier. Gone are the days of typing out every single word. Not only does it work offline on your computer, but it also packs a punch with its real-time speech recognition, batch transcription, and speaker recognition capabilities. EaseText - The Best Persian Farsi Speech to Text Transcription ToolĮaseText Audio to Text Converter is the ultimate tool for anyone who needs to transcribe Persian Farsi speech. You don't have to pay someone to transcribe for you, making this tech a great choice for your wallet. What's more, businesses can use it to transcribe speech in different languages, making it super helpful for global communication.Īnd let's not forget about the cost savings. If you have trouble hearing or if English isn't your first language, this tech makes it way easier to get the info you need. Plus, it's way more accurate than having a human transcribe, so you know you're getting a solid record.Īnother cool thing is that it makes things way more accessible. Instead of having to type everything out, you can just talk and the tech will do the typing for you. One of advantages of Persian Farsi speech to text is how it saves you time. Persian Farsi speech to text technology can be used for tasks such as minutes-taking in meetings, customer service call center support, and even in legal and medical settings to transcribe important audio recordings.Īdvantages of Persian Farsi Speech to Text.With the ability to transcribe spoken words into text, individuals with hearing impairments or other disabilities can better participate in and access information in the digital world. Additionally, the technology can be integrated into virtual personal assistants and smart home devices, making it easier to control these devices through voice commands. It allows individuals to easily convert their spoken words into written text. Persian Farsi speech to text technology has numerous applications across various industries and fields. Applications of Persian Farsi Speech to Text The result is a written transcript that accurately represents the spoken words, making it easier to process and store information, and reducing the need for manual transcription. This technology uses algorithms and machine learning techniques to analyze speech patterns and translate them into written words and sentences. ![]() So, what exactly is Persian Farsi speech to text technology? Simply put, it is a type of speech recognition technology that transcribes spoken Persian Farsi into written text. Explanation of Persian Farsi speech to text ![]() ![]() ![]() It is best to keep everyone alive during your collectible playthrough. This will allow you to get the maximum number of collectibles. You can also follow The Quarry Walkthrough (Everyone Survives), it will get you the trophies for all Evidence + all Tarots. If you grab everything possible (going to Rocky Road in Chapter 2) you should only have 2 clues left after the first playthrough: Hackett History #2, Hackett History #3. You can keep track of your Collectibles in the Pause Menu under Clues / Evidence / Tarots. They are all numbered and have unique names. Thus you can easily reference your missing ones in this guide. Some items are easy to miss when you advance towards the next cutscene. When using Chapter Select it resets your Collectible Progress to what you had at the start of that Chapter.There are some important notes about Chapter Select: This is pointed out in the guide but if you miss anything you can get it in the next Chapter Select playthrough. To pop the trophies you must have ALL collectibles of one type in one playthrough. When using Chapter Select to replay a Chapter, the Chapter Select becomes unavailable until beating the game again (from whatever chapter you start replaying you must finish all chapters until the end of the game again to re-unlock Chapter Select).If you try to get the mutually exclusive Chapter 2 collectibles (Rocky Road/Shady Glade) via Chapter Select it won’t pop the trophies, you must recollect completely everything. For example, if after the story you replay Chapter 2, you would have to again finish Chapters 2-10 all the way to the end of the story. It gives you +5 Finesse, +2 Constitution, +3 Wits, +20 percent Water Resistance, +1 Huntsman, +1 Sneaking, +234 HP, and full immunity to being Terrified or Charmed.Only then you unlock Chapter Select again. Head to the groom's house in Arx, and you'll find the helmet in a chest. This chest armor provides +5 Finesse, +3 Intelligence, +10 percent Fire Resistance, +10% percent Water Resistance, +1 Huntsman, +2 Scoundrel, +0.1 Movement, +176 HP, and deflects 20 percent of incoming melee damage from enemies as Water damage. They give you +3 Finesse, +2 Wits, +1 Scoundrel, +1 Sneaking, +1 Thievery, +6 Initiative, +0.5 Movement, and full immunity to some negative effects like Slowed, Crippled, and Knocked Down.įound in Sanguinia Tell's basement in Arx inside a chest. In Arx, cross the bridge to get to Lucian's Temple, and a trader will wait for you on the other side of the bridge, selling these boots. You'll gain the skill called Global Cooling when equipping it. 20 percent of melee damage is also reflected on enemies as Water damage. It provides +2 Finesse, +20 percent Water Resistance, +1 Ranged, +1 Sneaking, +1 Thievery, +0.25 Movement and +21 HP. On Reaper's Coast, head to the Black Bull tavern and speak to Papa Thrash, who sells this chest armor. It grants you +3 Finesse, +3 Wits, and +1 Thievery. These gloves grant you +1 Finesse, +10 percent Poison Resistance, and +1 Huntsman.Īs you head to the Nameless Isle, you must face off against the mysterious Shadow Prince. After defeating the Void Salamanders, speak to a squirrel nearby who will point you to the location of this hidden treasure. Damage dealt varies per your Finesse stat.Ī pair of gloves found on Fort Joy island. Your go-to area-of-effect spell that sends down a literal storm of arrows upon enemies. A single shot that deals 115 percent damage and gains an additional 50 percent damage bonus when fired while sneaking. ![]() If you chose Sneaking as one of your skills, this is a very powerful skill. Each arrow can target a different enemy for 60 percent damage.Īn absolute must-have bail-out skill, which lets your Ranger teleport to high ground or away easily, and also sets Haste on them.Ī very powerful shot that can pass through multiple enemies in a single line, going even through armor. The Ranger will fire a bouncing shot of 90 percent damage that switches to a target within five meters.Īnother great crowd control ability, which allows your Ranger to fire three arrows simultaneously. It dishes out a whopping 120 percent damage, too.Īgainst groups of enemies that stick close together, Ricochet allows a Ranger to chip away at their health from afar. It both heals and removes some negative status effects, such as Crippled, Blinded, or Poisoned.Ī powerful shot that has a chance of setting the Crippled status effect on the enemy, reducing their AP. A simple necessity, having this could mean the difference between life and death early in the game. ![]() ![]() ![]() It provides buttons to access these overlays and settings: Step 6: The Xbox Game Bar appears near your screen’s top-center edge. However, Xbox Game Bar does not record the desktop or File Explorer, it only opens with applications. Sure, it’s a lie, as Xbox Game Bar is meant for capturing gameplay, but this little fib extends this feature out to other applications. You may or may not see a prompt asking if the highlighted application on your screen is a game. Step 5: When you’re done adjusting your settings, type the default keyboard shortcut to open the Xbox Game Bar: Win + G. There are also options to enable recording while projecting your screen, set a maximum recording length, and adjust your audio settings and video quality settings. Under Captures, you can change your save location for your recordings and screenshots, enable background recording, and enable recordings even when your laptop isn’t plugged in. Step 4: Select Captures listed on the left to view and adjust further customization options if needed. As shown below, there’s a toggle under the second paragraph that should be set to On. Step 3: The Xbox Game Bar section should load by default. How to password protect a folder in Windows and macOS How to back up an iPhone using Mac, iCloud or PC How to set a default printer on Windows or Mac Step 2: Select Gaming in the Settings app. ![]() Both of these methods will open the Settings app. Step 1: Select the Start button, followed by the Gear icon located in the Start Menu.Īlternatively, you can select the Notifications message bubble icon on the taskbar and select the All settings tile in the Action Center. Nvidia NVENC (most Nvidia GeForce 600 or newer most Quadro K series or newer).Intel Quick Sync H.264 (Intel second-generation CPU or newer).Most modern graphics cards or processors support them. To use the Xbox Game Bar feature, your PC needs to support one of the following encoders. If you prefer step-by-step instructions for Windows 11, be sure to check out our Windows 11-specific screen recording how-to guide. However, Windows 11 will look a little different from the images we are using. Note: All steps for Windows devices will also all work on Windows 11, including options to use PowerPoint explained below. However, it can be used for any open application, offering a convenient way to record the screen and even add audio if needed. Windows 10 includes a native video capture tool, but it’s primarily designed for gamers. How to record your screen on Windows using Xbox Game Bar In this guide, we’ll show you how by using native, open-source, and paid third-party tools. The task is easier than you might think, as Windows 10/11, MacOS, and even Chrome OS have built-in tools that can get the job done. Device with Windows 10 (Computer, Xbox), Mac, or Chromebook ![]() ![]() ![]() Made from 100-percent cotton, the face of this ivory duvet cover features stripes of pompoms that add texture and dimension for a boho inspired look. Your refund will be processed via the same method of payment that you used to pay for your order.The Madison Park Tracie 3 Piece Pom Pom Duvet Cover Set offers a simple chic update to your bedroom decor. ![]() Once your returned items have been received, your refund will be processed within 10 working days. You’ll need to return your item in its original, unused condition using one of the return methods above and place a new order for the item you’d like. Unfortunately, we’re unable to exchange any orders placed online. You can cancel your order or items in your order before we dispatch them by accessing your account or contacting our Customer Care team. Unfortunately, we can’t refund items that have been damaged after delivery due to misuse, wear and tear, or accidents.Ĭhanged your mind about an item? You’ll need to return it in its original, unused condition and within 30 days of receipt. If you don’t receive your items within 14 working days of receiving a Dispatch Confirmation email, please contact our Customer Care team, quoting your order number, and we’ll investigate this for you. If your order arrives damaged or incomplete, please contact our Customer Care team immediately, quoting your order number and detailing the problem with your items. We take care to ensure all items arrive in perfect condition. Please keep the item safe and protected as it's your responsibility until it has been returned. Please ensure you retain proof of delivery as we cannot be held liable for items lost in transit.Ĭan't return your goods via the above methods? Get in touch with our Customer Care team and one of our agents will be able to explain your options. Once authorised, you can use the returns label provided once the return is raised.Ĭan't find your returns label? Don’t worry, just clearly mark your parcel with your returns number, full name and return it using a tracked delivery method to the below address: When posting your items back to us, it’s important that you first authorise your return by raising your return online or contacting our Customer Care team. ![]() If your item has arrived damaged, please contact our Customer Care team immediately, quoting your order number and detailing the problem with your items. Need to return an item you purchased online? There are a few ways you can do this, but you’ll need to return your item to us within 30 days of receiving it. ![]() Mattresses, mattress toppers, duvets and pillows can only be returned if they are unused, in the original packaging and in a resaleable condition Therefore perishable goods such as food and drink cannot be returned.įor reasons of hygiene and safety, personal grooming products, cosmetics or items of intimate clothing cannot be returned. Unwanted Food or Drink Products - Once supply conditions are broken, there are a number of factors outside of our control that can affect the quality of a product. Should one of these products prove to be faulty it can be returned with your receipt within 30 days and we will exchange it for one of the same title. Refunds and exchanges cannot be given against Audio/DVD and Computer Games. To qualify for a refund or replacement, products need to be complete with all components and original packaging. If you are not happy with a purchase you make at our stores, simply return it in its original condition, with proof of purchase, within 30 days and we’ll give you a full refund or replacement.*Ĭustomers are advised that refunds and credit notes will only be given where proof of purchase (receipt, credit card statement, etc) is provided. ![]() ![]() ![]() Meanwhile, in other countries 'solitaire' specifically refers to one-player board and table games, especially peg solitaire. are designed for one player" and that "Solitaire.properly applies to any game that one player can play alone." In practice, in North America the name 'solitaire' is often used totum pro parte to refer to single-player card games, although sometimes the term 'card solitaire' is used for clarity. in some systematic order." They note that "there are excellent games of Patience for two or more players but most. Īmerican games authors Wood and Goddard state that "Patience is any game played with playing cards in which the object is to arrange the cards. Secondly, any game of patience may be played competitively by two or more players. Firstly, a patience is a card game, whereas a solitaire is any one-player game, including those played with dominoes or peg and board games. The word is French in origin, these games being "regarded as an exercise in patience." Īlthough the name solitaire became common in North America for this type of game during the 20th century, British games scholar David Parlett notes that there are good reasons for preferring the name 'patience'. 'Patience' is the earliest recorded name for this type of card game in both British and American sources. Most are intended for play by a single player, but there are also "excellent games of patience for two or more players". Patience (Europe), card solitaire or solitaire (US/Canada), is a genre of card games whose common feature is that the aim is to arrange the cards in some systematic order or, in a few cases, to pair them off in order to discard them. The layout of the game known as Crazy Quilt ![]() ![]() We’ve made good on this promise of pulling off physics destruction in the cloud, which is this big technical lift, but I actually think it’s really fun too. I feel really good about where we’ve landed, especially on Wrecking Zone. Specifically around cloud-based destruction. I mean, as everybody knows, Crackdown has been in development for a long time and we very publicly stated some pretty lofty goals. ![]() You mentioned that you've been a fan of the series for a long time, back to your Halo 3 days - how exciting is it to be involved in this game, this close to launch? Where do you feel like you're at right now with regards to Crackdown 3? So in Crackdown, yeah, we were actually much more involved than usual, and I’ve been spending a lot of time in the UK with Sumo working on the campaign and just really being pretty deep in the game as we get closer to launch. Typically the publishing team - well, depends on different publishers…but Microsoft first party publishing tends to get a little bit more involved in the games because they typically are pushing technology that requires a lot of close coordination with Microsoft tech and design. So I sit on the publishing side of things and work with the dev teams to help make the games.Īnd how actively involved are you in Crackdown 3, specifically? I’m the creative director and head of design for Microsoft Global Publishing. Why don't we start with you introducing yourself and your role in Crackdown 3. Related: Crackdown 3 Is Exactly The Exclusive Xbox Needs Staten covered Crackdown 3's PvP, DLC plans, story mode design decisions, and more, and if freedom is what players want, then Crackdown 3 is poised to capitalize on that in a big way. If you're wondering how Crackdown 3 might compete with the other big games like Anthem, Staten recently sat down with Screen Rant for an interview. There have been delays, developer changes, and a host of other adversities, but the game is finally ready to be played and will debut alongside some stiff competition in mid-February. ![]() Now, as the creative director and head of design for Microsoft Global Publishing, Staten finds himself on the precipice of launching Crackdown 3, nine years after the last release in the series. ![]() ![]() ![]() But cybersecurity observers on both sides of the political divide say the results of that disconnect have been a surprisingly mixed bag: The ongoing SolarWinds debacle shows how Trump's disjointed, self-serving failures of leadership have left the federal government struggling to pull together a coherent response to one of America's most serious cybersecurity failures in years. On almost every significant cybersecurity issue of the past year, President Trump has appeared to be either AWOL or at war with his own federal agencies. Now, even as attorney general William Barr and secretary of state Mike Pompeo have pointed to Russia as the culprit, Trump has responded by downplaying the crisis, suggesting intrusions might have been carried out by China instead. ![]() This year was finally capped off by revelations of a disastrous hacking campaign that hijacked the software updates of IT management firm SolarWinds to breach a slew of federal agencies and tech firms. When CISA released a statement lauding the election as the " most secure in American history," contradicting the president's claims, Trump summarily fired CISA director Chris Krebs. In late October, the president made an absurd declaration at a campaign rally that “nobody gets hacked.” That same week, the Cybersecurity and Infrastructure Security Administration (CISA), Justice Department, and Treasury Department all took separate, landmark steps to counter Russian hacking- unsealing an indictment against six hackers in Russia's GRU military intelligence agency, imposing new sanctions on the Moscow research institute responsible for a uniquely dangerous piece of malware, and warning of an ongoing hacking campaign believed to be carried out by the FSB.Ī few weeks later, Donald Trump lost the election and laid the blame on false conspiracy theories about electoral hacking and fraud. When it comes to cybersecurity policy, the Trump administration's head and body have rarely seemed to agree. ![]() |